While the Colts likely plan to run through the Patriots‘ struggling run defense, New England is likely planning the opposite. The team will be without Damien Harris for their Saturday-night matchup in Indianapolis. Yodney Castuje will also be out, while the Pats recently placed Ronnie Perkins on injury reserve.

The team announced each move Friday.

Perkins has been dealing with an ankle injury the past three weeks, and the team placed him on IR after being listed as out prior. Harris (hamstring) was questionable before being ruled out, and so was Castuje (illness).

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